Applied Research · Nasal Care
Nasal mucosa,
rebuilding immune thresholds
Featured Indication
Seasonal & Perennial Pollen Allergy
Reconstructing the nasal immune microenvironment to break the cycle of recurrent allergies at the root and achieve a systemic rebuild toward immune tolerance.
Precisely downregulates overactive Th2 signaling and increases Treg regulatory weight to reset immune thresholds at the NALT level. Deeply repairs nasal mucosal tight-junction proteins and the local barrier, reducing sensory nerve hypersensitivity and severing the neuro-immune amplification chain of mild stimulus to severe symptoms.
Other Application Directions
Three System-Level Indications
The nasal delivery platform extends beyond local nasal action. Exosome barrier-crossing capability reaches the respiratory tract, cardiopulmonary axis, and CNS — all unified by the goal of immune microenvironment repair and homeostasis restoration.
Indication Category
Respiratory Diseases
Correcting Th1/Th2 imbalance and NF-kB / NLRP3 inflammatory axes to stabilize alveolar barriers through repair, not blunt suppression.
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Indication Category
Cardiopulmonary-Axis Diseases
Exosomes cross the alveolar barrier and home to ischemic myocardium via SDF-1 / CXCR4, activating anti-apoptotic signaling to open a repair window.
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Indication Category
Central Nervous System Diseases
BBB-crossing delivery reduces microglial overactivation, clears pathological proteins, and rebuilds a quieter CNS immune environment.
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Platform Technology
Three engineered pathways
Not single-agent symptom suppression, but standardized decellularized signaling modules derived from functional T-cell cytokine clusters and miRNA programs, delivered through synthetic biology exosomes.
Signal Modularization
Extracting regulatory cytokine groups and miRNA clusters into standardized engineered modules
Reusable regulatory signal combinations are extracted from functional T cells and packaged into decellularized, standardized modules that support immune rebalancing, inflammatory de-noising, and tissue repair with lower batch variability and higher configurability.
Delivery Engineering
Using synthetic biology exosomes for trans-mucosal, BBB-crossing, and lesion-targeted delivery
Exosomes support trans-mucosal absorption, alveolar-barrier transfer, BBB crossing, and lesion homing, allowing the platform to extend beyond local nasal action toward respiratory, cardiopulmonary, and CNS microenvironment regulation.
Threshold Rebuilding
Repairing immune microenvironments, lowering hyperreactivity, rebuilding immune thresholds
Across pollen allergy, pre-cytokine-storm states, post-ischemic myocardial apoptosis, or overactivated microglia, the shared goal is rebuilding local balance where the system can respond when needed without overreacting.
Next Step
Dive into pollen allergy detail or explore other applied directions
Pollen allergy is the lead indication for this direction. The detail page covers the full immune mechanism and partnership entry. Other directions share the same delivery platform.